{6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

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Chemical Name:{6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol
CAS No.:1378037-91-2
Molecular Formula:C₁₇H₁₁BrCl₂N₆O
Molecular Weight:466.124
Hs Code.:

Synonyms:{6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

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Chemical Property of {6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

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Technology Process of {6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

There total 3 articles about {6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 436851-94-4
(6-aminopyrimidin-4-yl)methanol

: 1378040-01-7
4,7-dibromo-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine

: 1378037-91-2
{6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 1h; Sealed tube; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1378039-99-6
7-bromo-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine

: 1378037-91-2
{6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane / 18 h / 20 °C

2: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 4.5 h / 0 - 20 °C

3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With dihydrogen peroxide; methyltrioxorhenium(VII); caesium carbonate; phosphorus(V) oxybromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1378040-00-6
7-Bromo-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-5-oxide

: 1378037-91-2
{6-[7-bromo-2-(2,6-dichloro-phenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 4.5 h / 0 - 20 °C

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With caesium carbonate; phosphorus(V) oxybromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1,2-dichloro-ethane;