(2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

Base Information

Chemical Name:(2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d
CAS No.:155325-81-8
Molecular Formula:C₁₀H₁₂FNO₃
Molecular Weight:214.201
Hs Code.:

Synonyms:(2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

Chemical Property:

Purity/Quality:

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Technology Process of (2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

There total 7 articles about (2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₀⁽²⁾HF₄NO₄

: 155325-81-8
(2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

Guidance literature:: With potassium carbonate; In methanol; at 25 ℃; for 12h; Yield given;

Reference yield:

: 73922-81-3,81555-86-4,104597-03-7,5876-76-6
4-phenyl-but-3-yn-2-ol

: 155325-81-8
(2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / lithium aluminum deuteride / tetrahydrofuran / 0 °C

2: 63 percent / tert-butyl hydroperoxide, L-(+)-diisopropyl tartrate, Ti(O-i-Pr)4, molecular sieves 3 A / CH₂Cl₂; decane; 2,2,4-trimethyl-pentane / -20 °C

3: 1.) sodium bis(2-methoxyethoxy)aluminum hydride, 2.) lead tetraacetate / 1.) THF, toluene, 25 deg C, 2.) benzene, 25 deg C, 10 min

4: 21 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / -78 - 25 °C

5: copper(II) nitrate / CHCl₃ / 3 h / 25 °C

6: potassium carbonate / methanol / 12 h / 25 °C

With lead(IV) acetate; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium deuteride; L-(+)-diisopropyl tartrate; diethylamino-sulfur trifluoride; 3 A molecular sieve; potassium carbonate; copper(II) nitrate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; 2,2,4-trimethylpentane; decane; dichloromethane; chloroform;

Reference yield:

: 77249-48-0
(E)-(2R,2S)-4-phenyl-3-buten-2-ol-3-d

: 155325-81-8
(2S,3S,4S)-4-fluoro-4-(4'-nitrophenyl)butan-2-ol-3-d

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / tert-butyl hydroperoxide, L-(+)-diisopropyl tartrate, Ti(O-i-Pr)4, molecular sieves 3 A / CH₂Cl₂; decane; 2,2,4-trimethyl-pentane / -20 °C

2: 1.) sodium bis(2-methoxyethoxy)aluminum hydride, 2.) lead tetraacetate / 1.) THF, toluene, 25 deg C, 2.) benzene, 25 deg C, 10 min

3: 21 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / -78 - 25 °C

4: copper(II) nitrate / CHCl₃ / 3 h / 25 °C

5: potassium carbonate / methanol / 12 h / 25 °C

With lead(IV) acetate; titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; diethylamino-sulfur trifluoride; 3 A molecular sieve; potassium carbonate; copper(II) nitrate; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; 2,2,4-trimethylpentane; decane; dichloromethane; chloroform;