4-(3-Nitrophenyl)pyridine

Base Information

• Chemical Name: 4-(3-Nitrophenyl)pyridine
• CAS No.: 4282-48-8
• Molecular Formula: C11H8N2O2
• Molecular Weight: 200.197
• Hs Code.: 2933399090
• Mol file: 4282-48-8.mol

Synonyms:Pyridine,4-(m-nitrophenyl)- (6CI,7CI,8CI);4-(m-Nitrophenyl)pyridine;

Chemical Property of 4-(3-Nitrophenyl)pyridine

Chemical Property:

• Vapor Pressure: 9.44E-05mmHg at 25°C
• Melting Point: 109-110 °C
• Refractive Index: 1.611
• Boiling Point: 349.516 °C at 760 mmHg
• PKA: 4.95±0.10(Predicted)
• Flash Point: 165.181 °C
• PSA: 58.71000
• Density: 1.253 g/cm³
• LogP: 3.18000

Purity/Quality:

97% ^*data from raw suppliers

4-(3-Nitrophenyl)pyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-Nitrophenyl)pyridine

There total 10 articles about 4-(3-Nitrophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(meta-nitrophenyl)-1,4-dihydropyridine → 4-(3-nitrophenyl)pyridine (4282-48-8)

Guidance literature:

With dipotassium peroxodisulfate; In acetonitrile; for 2.5h; Heating;

Reference yield: 72.0%

m-nitrobenzene boronic acid (13331-27-6) + 4-bromopyridine hydrochloride (19524-06-2) → 4-(3-nitrophenyl)pyridine (4282-48-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 130 ℃; for 0.75h; Sealed tube; Inert atmosphere; Microwave irradiation;

DOI:10.1002/anie.202006943

Reference yield: 67.0%

→ 4-(3-nitrophenyl)pyridine (4282-48-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; for 16h; Reflux; Inert atmosphere;

upstream raw materials:

pyridine

3-nitrophenyldiazonium chloride

sulfuric acid

1,2-dimethoxyethane

Downstream raw materials:

3-nitrobenzoic acid

3-(pyridin-4-yl)benzenamine

4-(3-nitrophenyl)pyridine 1-oxide

1-Acetyl-4-(3-nitrophenyl)-1,2,5,6-tetrahydropyridine