[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

Base Information

Chemical Name:[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride
CAS No.:1091681-67-2
Molecular Formula:C₂₇H₃₇N₃O₃*ClH
Molecular Weight:488.07
Hs Code.:

Synonyms:[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

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Chemical Property of [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

Chemical Property:

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Technology Process of [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

There total 5 articles about [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride: 1091681-67-2
[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

2: sodium hydroxide / water; tetrahydrofuran / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

: 1091681-69-4
4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride: 1091681-67-2
[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; ethyl acetate / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride: 1091681-67-2
[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

2: sodium hydroxide / water; tetrahydrofuran / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2016.04.086