5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

Base Information

Chemical Name:5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate
CAS No.:98293-14-2
Molecular Formula:C₄₆H₃₉Cl₃N₃O₁₀P
Molecular Weight:931.163
Hs Code.:

Synonyms:5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

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Chemical Property of 5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

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Technology Process of 5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

There total 3 articles about 5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 93636-01-2
2,6-dichlorophenyl 5-chloro-8-quinolyl phosphorochloridate

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 98293-14-2
5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; for 0.75h;
DOI:10.1246/cl.1985.347

Reference yield:

: 130-16-5
5-Chloro-8-hydroxyquinoline

: 98293-14-2
5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / -10 deg C to room temp.

2: 85 percent / 1-methylimidazole / tetrahydrofuran / 0.75 h

With 1-methyl-1H-imidazole; triethylamine; In tetrahydrofuran;
DOI:10.1246/cl.1985.347

Reference yield:

: 53676-19-0
2,6-dichlorophenyl phosphorodichloridate

: 98293-14-2
5'-O-dimethoxytritylthymidine 3'-(2,5-dichlorophenyl, 5-chloro-8-quinolyl) phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / -10 deg C to room temp.

2: 85 percent / 1-methylimidazole / tetrahydrofuran / 0.75 h

With 1-methyl-1H-imidazole; triethylamine; In tetrahydrofuran;
DOI:10.1246/cl.1985.347