Technology Process of (2S,3R,5R)-3-Chlorocarbonyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester
There total 8 articles about (2S,3R,5R)-3-Chlorocarbonyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sulfuric acid; potassium bromide; sodium nitrite / ethanol / 3.5 h / 6 - 8 °C
2: peracetic acid; potassium iodide / dichloromethane; water / 1 h / 0 °C
3: acetic acid; zinc / acetonitrile / 1 h / 0 °C
4: toluene / 2 h / 114 °C
5: silver(I) acetate / dichloromethane / 4 h / 20 °C
6: potassium permanganate; acetic acid / water; acetone / 1 h / 20 °C
7: thiourea / ethanol / 1 h / 70 °C
8: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
9: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; tert-butyl alcohol / 1 h / 20 °C
10: pyridine; oxalyl dichloride / dichloromethane / 1 h / 20 °C
With
pyridine; peracetic acid; sodium chlorite; potassium permanganate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; sulfuric acid; silver(I) acetate; Dess-Martin periodane; acetic acid; thiourea; potassium iodide; potassium bromide; zinc; sodium nitrite;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1128/AAC.06099-11
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
2: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; tert-butyl alcohol / 1 h / 20 °C
3: pyridine; oxalyl dichloride / dichloromethane / 1 h / 20 °C
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1128/AAC.06099-11