methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate

Base Information

• Chemical Name: methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate
• CAS No.: 1622104-34-0
• Molecular Formula: C₁₂H₁₃IO₆
• Molecular Weight: 380.136
• Mol file: 1622104-34-0.mol

Synonyms:methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate

Chemical Property of methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate

There total 3 articles about methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

chloromethyl methyl ether (107-30-2) + methyl 6-formyl-3-hydroxy-4-iodo-2-methoxybenzoate (842150-44-1) → methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate (1622104-34-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1002/anie.201400315

Reference yield:

vanillin (121-33-5,8014-42-4) → methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate (1622104-34-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert-butyldimethylsilyl chloride / Inert atmosphere

1.2: Inert atmosphere

2.1: tetramethylammonium dichloroiodate(I) / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

With tetramethylammonium dichloroiodate(I); tert-butyldimethylsilyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201601224

Reference yield:

methyl 6-formyl-3-hydroxy-2-methoxybenzoate (842150-43-0) → methyl 6-formyl-4-iodo-2-methoxy-3-(methoxymethoxy)benzoate (1622104-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetramethylammonium dichloroiodate(I) / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

With tetramethylammonium dichloroiodate(I); N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201601224

upstream raw materials:

chloromethyl methyl ether

methyl 6-formyl-3-hydroxy-4-iodo-2-methoxybenzoate

vanillin

methyl 6-formyl-3-hydroxy-2-methoxybenzoate