2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid

Base Information

• Chemical Name: 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid
• CAS No.: 204528-00-7
• Molecular Formula: C₁₇H₂₀N₄O₅
• Molecular Weight: 360.37
• Mol file: 204528-00-7.mol

Synonyms:2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid

Chemical Property of 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid

There total 2 articles about 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-amino-hexanoic acid (616-06-8) + 1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester (204527-99-1) → 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid (204528-00-7)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 3.5h;

DOI:10.1080/00397919808005949

Reference yield:

5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid (69195-96-6) → 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid (204528-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 1,3-dicyclohexylcarbodiimide / ethyl acetate; dimethylformamide / 1) 0 deg C, 1 h; 2) rt, 1 h

2: 83 percent / dimethylformamide / 3.5 h / 60 °C

With dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1080/00397919808005949

Reference yield:

2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid (204528-00-7) → 3-Benzyl-6-butyl-3,4,6,7-tetrahydro-imidazo[4,5-e][1,4]diazepine-5,8-dione

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

2: 78 percent / H₂ / Pd-C / methanol / 0.75 h / 2068.6 Torr / Ambient temperature

3: 44 percent / potassium tert-butoxide / dimethylformamide; tetrahydrofuran / 3 h / Ambient temperature

With potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397919808005949

upstream raw materials:

2-amino-hexanoic acid

1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester

5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid

Downstream raw materials:

2-[(5-Amino-1-benzyl-1H-imidazole-4-carbonyl)-amino]-hexanoic acid methyl ester