N-(Piperidin-4-ylmethyl)pyrimidin-2-amine

Base Information

Chemical Name:N-(Piperidin-4-ylmethyl)pyrimidin-2-amine
CAS No.:521273-76-7
Molecular Formula:C10H16N4
Molecular Weight:192.264
Hs Code.:
DSSTox Substance ID:DTXSID90582981
Wikidata:Q72500834
Mol file:521273-76-7.mol

Synonyms:521273-76-7;N-(PIPERIDIN-4-YLMETHYL)PYRIMIDIN-2-AMINE;PIPERIDIN-4-YLMETHYL-PYRIMIDIN-2-YL-AMINE;N-(4-piperidylmethyl)pyrimidin-2-amine;2-Pyrimidinamine,N-(4-piperidinylmethyl)-;MFCD11974773;SCHEMBL761678;DTXSID90582981;RYUCGGGAQDYSMJ-UHFFFAOYSA-N;AC8624;AKOS011066267;SY264686;CS-0108087;N-[(Piperidin-4-yl)methyl]pyrimidin-2-amine

Suppliers and Price of N-(Piperidin-4-ylmethyl)pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Piperidin-4-ylmethyl-pyrimidin-2-YL-amine
250mg
$ 802.00

Total 11 raw suppliers

Chemical Property of N-(Piperidin-4-ylmethyl)pyrimidin-2-amine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:73-75 °C
Refractive Index:1.563
Boiling Point:349.62 °C at 760 mmHg
PKA:10.48±0.10(Predicted)
Flash Point:165.244 °C
PSA：49.84000
Density:1.106 g/cm³
LogP:1.28990
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:192.137496527
Heavy Atom Count:14
Complexity:150

Purity/Quality:

98%min ^*data from raw suppliers

Piperidin-4-ylmethyl-pyrimidin-2-YL-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1CNC2=NC=CC=N2

Technology Process of N-(Piperidin-4-ylmethyl)pyrimidin-2-amine

There total 5 articles about N-(Piperidin-4-ylmethyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157023-34-2
4-aminomethyl-piperidine-1-carboxylic acid benzyl ester

: 521273-76-7
4-(piperidin-4-ylmethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / Cs₂CO₃ / dimethylformamide / 18 h / 70 °C

2: H₂ / Pd/C / ethanol / 18 h

With hydrogen; caesium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm060983w

Reference yield:

: 455265-24-4
benzyl 4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate

: 521273-76-7
4-(piperidin-4-ylmethyl)pyrimidin-2-amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 18h;
DOI:10.1021/jm060983w

Reference yield:

: 7144-05-0
4-Aminomethylpiperidine

: 521273-76-7
4-(piperidin-4-ylmethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; benzaldehyde / tetrahydrofuran; dichloromethane; toluene

2: caesium carbonate / hexane; N,N-dimethyl-formamide

3: palladium-carbon / methanol

With hydrogenchloride; caesium carbonate; benzaldehyde; palladium-carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;