157023-34-2

Basic information

• Product Name: 1-Cbz-4-Aminomethylpiperidine
• Synonyms: BENZYL 4-(AMINOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;BUTTPARK 93\50-51;4-(AMINOMETHYL)PIPERIDINE, N-CBZ PROTECTED;4-AMINOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;4-AMINOMETHYL-1-N-CBZ-PIPERIDINE;1-CBZ-4-AMINOMETHYLPIPERIDINE;N-CBZ-4-AMINOMETHYLPIPERIDINE;4-(AMINOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• CAS NO: 157023-34-2
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Mol File: 157023-34-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 385.709 °C at 760 mmHg
• Flash Point: 187.07 °C
• Appearance: /
• Density: 1.126 g/cm³
• PKA: 10.13±0.29(Predicted)
• CAS DataBase Reference: 1-Cbz-4-Aminomethylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cbz-4-Aminomethylpiperidine(157023-34-2)
• EPA Substance Registry System: 1-Cbz-4-Aminomethylpiperidine(157023-34-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 157023-34-2(Hazardous Substances Data)

Usage

General Description

1-Cbz-4-Aminomethylpiperidine is a chemical compound that is commonly used in organic synthesis as a building block for various pharmaceuticals and biologically active molecules. It is a piperidine derivative with a Cbz (carboxybenzyl) protecting group attached to the amine group, which makes it a useful intermediate in the synthesis of compounds such as antipsychotics, analgesics, and antihistamines. 1-Cbz-4-Aminomethylpiperidine has a wide range of applications in the pharmaceutical industry due to its ability to act as a versatile intermediate for the synthesis of diverse bioactive molecules.

Upstream product

• 31139-36-3 dibenzyl dicarbonate 
• 7144-05-0 4-Aminomethylpiperidine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 501-53-1 benzyl chloroformate 
• 153747-01-4 4-(phthalimidomethyl)piperidine 
• 71207-29-9 N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine 
• 396072-76-7 N-(1-benzyloxycarbonylpiperidin-4-ylmethyl)phthalimide 

Downstream Products

• 471254-24-7 benzyl 4-[({[2-(methylsulfonyl)pyrimidin-4-yl]carbonyl}amino)methyl]piperidine-1-carboxylate 
• 1417453-04-3 benzyl 4-{[({2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-5-yl}carbonyl)amino]methyl}piperidine-1-carboxylate 
• 1093396-13-4 benzyl 4-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)piperidine-1-carboxylate 
• 441055-93-2 C₃₅H₃₉N₇O₂ 
• 455266-45-2 4-[(3-fluoro-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester 
• 455265-96-0 4-(Pteridin-4-ylaminomethyl)-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

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Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.

N-SUBSTITUTED-N'-SUBSTITUTED UREA DERIVATIVE AND USE THEREOF AS TNF-γ(a) PRODUCTION INHIBITOR

N-Substituted-N'-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF- α production inhibitory activity.

SRC kinase inhibitor compounds

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of proteins tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.