(3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

Base Information

Chemical Name:(3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine
CAS No.:290832-20-1
Molecular Formula:C₃₀H₃₁Cl₂N₃O
Molecular Weight:520.502
Hs Code.:

Synonyms:(3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

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Chemical Property of (3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

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Technology Process of (3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

There total 6 articles about (3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290832-49-4
(2S)-1-methyl-2-(phenylmethyl)piperazine

: 290832-35-8
5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoic acid

: 290832-20-1
(3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

Guidance literature:: (2S)-1-methyl-2-(phenylmethyl)piperazine; 5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoic acid; With benzotriazol-1-ol; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: (S)-N-(2-{N-[(1,1-dimethylethoxy)carbonyl](methyl)amino}-1-oxo-3-phenylpropyl)glycine methyl ester

: 290832-20-1
(3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

2.1: toluene / 42 h / 170 °C / Sealed tube

3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Reflux

4.1: benzotriazol-1-ol; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 2 h / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

Reference yield:

: 102185-45-5
N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-phenylalanine dicyclohexylamine salt

: 290832-20-1
(3S)-1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}-4-methyl-3-(phenylmethyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / dichloromethane; water

1.2: 0.17 h / 0 °C

1.3: 3 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

3.1: toluene / 42 h / 170 °C / Sealed tube

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Reflux

5.1: benzotriazol-1-ol; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

5.2: 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;