10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

Base Information

Chemical Name:10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol
CAS No.:228701-37-9
Molecular Formula:C₂₅H₂₈O₇
Molecular Weight:440.493
Hs Code.:

10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1<i>H</i>-benzo[<i>g</i>]isochromen-1-ol

Synonyms:10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

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Chemical Property of 10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

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Technology Process of 10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

There total 6 articles about 10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 206058-80-2
(3S,4R)-10-Benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-benzo[g]isochromen-1-one

: 228701-37-9
10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h;
DOI:10.7164/antibiotics.51.383

Reference yield:

: 6110-37-8
methyl 2,4-dimethoxy-6-methylbenzoate

: 228701-37-9
10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / LDA / tetrahydrofuran / 4.5 h / -78 - 0 °C

2: 89 percent / cyclohexene / 10 percent Pd-C / toluene / 12 h / 20 °C

3: 97 percent / K₂CO₃ / acetone / 7 h / 55 °C

4: DIBAL / toluene / 2 h / -78 °C

With diisobutylaluminium hydride; potassium carbonate; lithium diisopropyl amide; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; acetone; toluene; 1: Cycloaddition / 2: Aromatisation / 3: Etherification / 4: Reduction;
DOI:10.7164/antibiotics.51.383

Reference yield:

: 54826-92-5
(5R,6S)-5,6-dihydro-5-hydroxy-6-methylpyran-2-one

: 228701-37-9
10-benzyloxy-7,9-dimethoxy-4-methoxymethoxy-3-methyl-3,4-dihydro-1H-benzo[g]isochromen-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / P₂O₅ / CH₂Cl₂ / 0.25 h / 20 °C

2: 85 percent / LDA / tetrahydrofuran / 4.5 h / -78 - 0 °C

3: 89 percent / cyclohexene / 10 percent Pd-C / toluene / 12 h / 20 °C

4: 97 percent / K₂CO₃ / acetone / 7 h / 55 °C

5: DIBAL / toluene / 2 h / -78 °C

With phosphorus pentoxide; diisobutylaluminium hydride; potassium carbonate; lithium diisopropyl amide; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetone; toluene; 1: Substitution / 2: Cycloaddition / 3: Aromatisation / 4: Etherification / 5: Reduction;
DOI:10.7164/antibiotics.51.383