tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate

Base Information

• Chemical Name: tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate
• CAS No.: 1000068-32-5
• Molecular Formula: C₂₇H₂₇N₃O₅
• Molecular Weight: 473.528
• Mol file: 1000068-32-5.mol

Synonyms:tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate

Chemical Property of tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate

There total 1 articles about tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

tert-butyl 2-(5-aminopyridin-3-yl)-1H-indole-1-carboxylate (1000068-56-3) + 3-methoxy-4-trifluoromethane-sulfonyloxy-benzoic acid methyl ester (175153-75-0) → tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate (1000068-32-5)

Guidance literature:

With potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; for 16h; Heating / reflux;

Reference yield: 67.0%

tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate (1000068-32-5) → 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoic acid (1000068-33-6)

Guidance literature:

tert-butyl methyl 4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoate-1-carboxylate; With hydrogenchloride; In tetrahydrofuran; for 1h; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; ethanol; for 1h; Heating / reflux;

upstream raw materials:

tert-butyl 2-(5-aminopyridin-3-yl)-1H-indole-1-carboxylate

3-methoxy-4-trifluoromethane-sulfonyloxy-benzoic acid methyl ester

Downstream raw materials:

4-{[5-(1H-indol-2-yl)pyridin-3-yl]amino}-3-methoxybenzoic acid