175153-75-0

Basic information

• Product Name: Benzoic acid, 3-methoxy-4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester
• CAS NO: 175153-75-0
• Molecular Formula: C10H9F3O6S
• Molecular Weight: 314.239
• Mol File: 175153-75-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-methoxy-4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-methoxy-4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester(175153-75-0)
• EPA Substance Registry System: Benzoic acid, 3-methoxy-4-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester(175153-75-0)

Safety Data

• Hazardous Substances Data: 175153-75-0(Hazardous Substances Data)

Upstream product

• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 870837-21-1 3-methoxy-4-(4-methylimidazol-1-yl)benzoic acid methyl ester 
• 849757-76-2 4-(3-trifluoromethylpyridin-2-yl)-3-methoxybenzoic acid 
• 849757-85-3 4-(3-methoxypyridin-2-yl)-3-methoxybenzoic acid 
• 849757-71-7 4-(3-chloro-pyridin-2-yl)-3-methoxybenzoic acid 
• 3889-89-2 mukoeic acid 
• 957206-26-7 (4-isobutyl-3-methoxyphenyl)methanol 
• 849758-14-1 4-(methoxycarbonyl)-2-methoxyphenylboronic acid 
• 499218-36-9 3-methoxy-4-tributylstannanyl-benzoic acid methyl ester 
• 175152-72-4 methyl 3-methoxy-4-phenylbenzoate 

Relevant articles and documents

Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives

We synthesized a series of macrocyclic bis(bibenzyl) derivatives, including riccardin-, isoplagiochin- and marchantin-class structures, and evaluated their antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Th

Palladium-Catalyzed Cyclobutanation of Aryl Sulfonates through both C-O and C-H Cleavage

A palladium-catalyzed cyclobutanation of aryl sulfonates with strained alkenes has been developed. The methodology is featured to achieve the cleavage of both C-O and C-H bonds of phenol derivatives in one pot. Under the reaction conditions, in addition t

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. While it has been revealed that the modulation of the S1P1 receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P3 receptor is implicated in some undesirable effects. We carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of 13n as a clinical candidate that exhibited >30 000-fold selectivity for S1P1 over S1P3 and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED50 = 0.029 mg/kg, 24 h after oral dosing).