N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide
• CAS No.: 1242061-78-4
• Molecular Formula: C₁₅H₁₅NO₃S
• Molecular Weight: 289.355
• Mol file: 1242061-78-4.mol

Synonyms:N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property of N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide

There total 11 articles about N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-toluenesulfonyl azide (941-55-9) + 2-methylphenyl aldehyde (529-20-4) → N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide (1242061-78-4)

Guidance literature:

With silver hexafluoroantimonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 2-amino-4-trifluoromethylbenzoic acid; In ethanol; at 80 ℃; for 12h; Reagent/catalyst; Solvent; Sealed tube;

DOI:10.1055/s-0036-1591765

Reference yield: 93.0%

4-toluenesulfonyl azide (941-55-9) + N-(4-methoxyphenyl)-1-(o-tolyl)methanimine (173779-03-8) → N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide (1242061-78-4)

Guidance literature:

4-toluenesulfonyl azide; N-(4-methoxyphenyl)-1-(o-tolyl)methanimine; With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) hexafluorophosphate; In 1,2-dichloro-ethane; at 100 ℃; for 12h; Sealed tube; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1002/chem.201603805

Reference yield: 89.0%

4-toluenesulfonyl azide (941-55-9) + N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide (343598-64-1) → N-(2-formyl-3-methylphenyl)-4-methylbenzenesulfonamide (1242061-78-4)

Guidance literature:

4-toluenesulfonyl azide; N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide; With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) triflimide; In 1,2-dichloro-ethane; at 60 ℃; for 12h; Schlenk technique;

With hydrogenchloride; In water; at 20 ℃; for 3h; Solvent; Reagent/catalyst; Temperature; Catalytic behavior; Schlenk technique;

DOI:10.1021/acs.orglett.6b02406

upstream raw materials:

4-toluenesulfonyl azide

N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide

N-(4-methoxyphenyl)-1-(o-tolyl)methanimine

2-methylphenyl aldehyde

Downstream raw materials:

6-methyl-1-tosyl-1H-benzo[b]azepin-3(2H)-one

N-(2-formyl-3-methylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide