(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Base Information

• Chemical Name: (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide
• CAS No.: 1401624-29-0
• Molecular Formula: C₂₅H₃₁N₅O₃S
• Molecular Weight: 481.619
• Mol file: 1401624-29-0.mol

Synonyms:(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Chemical Property of (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

There total 13 articles about (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide (1401624-74-5) → (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide (1401624-29-0)

Guidance literature:

Boc-(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide; With formic acid; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

C30H39N5O5S → (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide (1401624-29-0)

Guidance literature:

With formic acid; at 20 ℃; for 4h;

DOI:10.1016/j.bcp.2019.04.006

Reference yield:

methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate → (S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide (1401624-29-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 3

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: formic acid / 4 h / 20 °C

With 4-methyl-morpholine; formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

tert-butyl (S)-1-((1S,2S)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

Boc-(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

p-bromobenzaldehyde tosylhydrazone