(1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

Base Information

• Chemical Name: (1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate
• CAS No.: 1401624-70-1
• Molecular Formula: C₃₁H₄₂N₄O₇S
• Molecular Weight: 614.763
• Mol file: 1401624-70-1.mol

Synonyms:(1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

Chemical Property of (1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

There total 1 articles about (1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate + Boc-Abu (34306-42-8) → (1R,2R)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate (1401624-69-8) + (1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate (1401624-70-1)

Guidance literature:

Boc-Abu; With 4-methyl-morpholine; chloroformic acid ethyl ester; In dichloromethane; at 0 ℃; for 1h;

methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate; In dichloromethane; at 20 ℃;

Reference yield:

(1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate (1401624-70-1) → C30H40N4O7S

Guidance literature:

(1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; pH=3;

Reference yield:

(1S,2S)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate (1401624-70-1) → tert-butyl (S)-1-((1S,2S)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate (1401624-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

1.2: pH 3

2.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane;

upstream raw materials:

Boc-Abu

Downstream raw materials:

tert-butyl (S)-1-((1S,2S)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

Boc-(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

(S)-2-amino-N-((1S,2S)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide