5-Pyrimidineacetic acid

Base Information

• Chemical Name: 5-Pyrimidineacetic acid
• CAS No.: 5267-07-2
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933599090
• Mol file: 5267-07-2.mol

Synonyms:5-Pyrimidineacetic acid;5-Pyrimidineaceticacid(7CI,8CI,9CI);5-PYRIMIDINEACETIC ACID,98%;5-Pyrimidineacetate

Chemical Property of 5-Pyrimidineacetic acid

Chemical Property:

• Vapor Pressure: 0.000188mmHg at 25°C
• Melting Point: 172-173 °C
• Refractive Index: 1.562
• Boiling Point: 315.1 °C at 760 mmHg
• PKA: 3.78±0.10(Predicted)
• Flash Point: 144.4 °C
• PSA: 63.08000
• Density: 1.336 g/cm³
• LogP: 0.10370
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(Pyrimidin-5-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (Pyrimidin-5-yl)acetic Acid was used in the study of preparation of benzimidazolone muscarinic antagonists, for potential treatment and/or prevention of myopia (nearsightedness). It was also used to prepare fused imidazole derivatives.

Technology Process of 5-Pyrimidineacetic acid

There total 1 articles about 5-Pyrimidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(pyrimidin-5-yl)acetic acid (5267-07-2)

Guidance literature:

Pyrimidin-5-yl-essigsaeure-aethylester, wss.NaOH (40grad);

Reference yield: 87.0%

2-(pyrimidin-5-yl)acetic acid (5267-07-2) + 4-Bromo-benzene-1,2-diamine (1575-37-7) → N-(2-amino-5-bromophenyl)-2-(pyrimidin-5-yl)acetamide (1396396-55-6)

Guidance literature:

With triethylamine; HATU; In dichloromethane; at 20 ℃;

Reference yield: 76.0%

2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(piperidin-4-yl)ethan-1-ol dihydrochloride + 2-(pyrimidin-5-yl)acetic acid (5267-07-2) → 1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyrimidin-5-yl)ethanone (1402837-29-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00662

Downstream raw materials:

N-(2-amino-5-bromophenyl)-2-(pyrimidin-5-yl)acetamide

5-bromo-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

C₂₇H₂₉FN₄O₂

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