5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

Base Information

Chemical Name:5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole
CAS No.:1396391-56-2
Molecular Formula:C₁₈H₁₂ClFN₄
Molecular Weight:338.771
Hs Code.:

Synonyms:5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

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Chemical Property of 5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

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Technology Process of 5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

There total 5 articles about 5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1396396-56-7
5-bromo-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

: 144432-85-9
3-chloro-4-fluorophenylboronic acid

: 1396391-56-2
5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; toluene; at 130 ℃;

Reference yield:

: 5267-07-2
2-(pyrimidin-5-yl)acetic acid

: 1396391-56-2
5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / dichloromethane / 20 °C

2: acetic acid / tetrahydrofuran / 3 h / 145 °C / microwave irradiation

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 130 °C

With sodium carbonate; acetic acid; triethylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1396391-56-2
5-(3-chloro-4-fluorophenyl)-2-(pyrimidin-5-ylmethyl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / dichloromethane / 20 °C

2: acetic acid / tetrahydrofuran / 3 h / 145 °C / microwave irradiation

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 130 °C

With sodium carbonate; acetic acid; triethylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; toluene;