4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

Base Information

• Chemical Name: 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione
• CAS No.: 1394240-72-2
• Molecular Formula: C₁₀H₁₂N₄O₂S₂
• Molecular Weight: 284.363

Synonyms:4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

Chemical Property of 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

Chemical Property:

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Technology Process of 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

There total 2 articles about 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

carbon disulfide (75-15-0,12122-00-8) + 2-(4-(methylsulfonyl)phenyl)acetohydrazide (428508-13-8) → 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione (1394240-72-2)

Guidance literature:

carbon disulfide; 2-(4-(methylsulfonyl)phenyl)acetohydrazide; With potassium hydroxide; In ethanol; at 20 ℃; for 10h;

With hydrazine hydrate; In ethanol; at 80 ℃; for 3h;

With hydrogenchloride; In ethanol; water; at 5 ℃; pH=2.5;

DOI:10.1016/j.ejmech.2012.04.024

Reference yield:

4-(methylsulfonyl)phenylacetic acid (90536-66-6) → 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione (1394240-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 80 °C

2.1: hydrazine hydrate / ethanol / 10 h / 80 °C

3.1: potassium hydroxide / ethanol / 10 h / 20 °C

3.2: 3 h / 80 °C

3.3: 5 °C / pH 2.5

With sulfuric acid; hydrazine hydrate; potassium hydroxide; In ethanol;

DOI:10.1016/j.ejmech.2012.04.024

Reference yield: 89.0%

4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2,4]-triazole-3-thione (1394240-72-2) + Brommethyl-2,7-dichlor-4-fluorenyl-keton (53221-22-0) → C25H18Cl2N4O2S2 (1394240-82-4)

Guidance literature:

In ethanol; at 80 ℃; for 5h;

DOI:10.1016/j.ejmech.2012.04.024

upstream raw materials:

carbon disulfide

2-(4-(methylsulfonyl)phenyl)acetohydrazide

4-(methylsulfonyl)phenylacetic acid

Downstream raw materials:

6-(2,5-dichloro-3-thienyl)-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazine

3-{3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl}-1H-isochromen-1-one

C₂₅H₁₈Cl₂N₄O₂S₂

2-hydroxy-5-{3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl}benzamide

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