2,6-dichloro-3-nitrobenzene-1-sulfonyl chloride

Base Information

• Chemical Name: 2,6-dichloro-3-nitrobenzene-1-sulfonyl chloride
• CAS No.: 276702-53-5
• Molecular Formula: C₆H₂Cl₃NO₄S
• Molecular Weight: 290.511
• Mol file: 276702-53-5.mol

Synonyms:2,6-dichloro-3-nitrobenzenesulfonyl chloride

Chemical Property of 2,6-dichloro-3-nitrobenzene-1-sulfonyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-dichloro-3-nitrobenzene-1-sulfonyl chloride

There total 4 articles about 2,6-dichloro-3-nitrobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,6-dichloro-3-nitrobenzenesulfonic acid dihydrate → 2,6-dichloro-3-nitrobenzenesulfonyl chloride (276702-53-5)

Guidance literature:

With potassium hydroxide; phosphorus pentachloride; trichlorophosphate; In methanol; water; ethyl acetate;

Reference yield:

2,6-dichlorobenzenesulfonyl chloride (6579-54-0) → 2,6-dichloro-3-nitrobenzenesulfonyl chloride (276702-53-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LiOH / methanol

2.1: H₂SO₄; HNO₃

3.1: KOH

3.2: POCl₃; PCl₅

With potassium hydroxide; lithium hydroxide; sulfuric acid; nitric acid; In methanol;

DOI:10.1016/j.bmcl.2006.12.067

Reference yield:

2,6-dichloro-3-nitrobenzenesulfonic acid (276702-52-4) → 2,6-dichloro-3-nitrobenzenesulfonyl chloride (276702-53-5)

Guidance literature:

2,6-dichloro-3-nitrobenzenesulfonic acid; With potassium hydroxide;

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1016/j.bmcl.2006.12.067

upstream raw materials:

2,6-dichloro-3-nitrobenzenesulfonic acid

2,6-dichlorobenzenesulfonyl chloride

o-dichlorobenzenesulfonic acid

Downstream raw materials:

2,6-dichloro-3-nitrobenzenesulfonamide

3-[3-([1,4']Bipiperidinyl-1'-sulfonyl)-4-chloro-2-hydroxy-phenylamino]-4-chloro-cyclobut-3-ene-1,2-dione

3-Chloro-4-[4-chloro-2-hydroxy-3-(4-methyl-[1,4]diazepane-1-sulfonyl)phenylamino]-cyclobut-3-ene-1,2-dione

2-([1,4']bipiperidinyl-1'-sulfonyl)-3-chloro-6-nitro-phenol

Refernces

• 1、 -. "Il-8 receptor antagonists". . . Retrieved 2008/06/13.
• 2、 -. "Il-8 receptor antagonists". . . Retrieved 2008/06/13.