4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Base Information

Chemical Name:4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine
CAS No.:1257079-01-8
Molecular Formula:C₂₃H₂₆ClN₇OS
Molecular Weight:484.025
Hs Code.:

Synonyms:4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Suppliers and Price of 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

There total 9 articles about 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1089279-91-3
1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine

: 1257079-00-7
6-chloro-5-(2-chloropyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1257079-01-8
4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Guidance literature:: 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine; 6-chloro-5-(2-chloropyrimidin-4-yl)imidazo[2,1-b]thiazole; With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 75 ℃; for 72h;

With sodium hydroxide; In 1,4-dioxane; water; isopropyl alcohol; pH=~ 13;

Reference yield:

: 50533-97-6
dimethyl-piperidin-4-yl-amine

: 1257079-01-8
4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 70 °C

1.2: pH 12 - 14

2.1: iron; ammonium chloride / ethanol; water / 1.5 h / 100 °C / pH 12 - 14

3.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 72 h / 75 °C

3.2: pH ~ 13

With hydrogenchloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 23576-81-0
6-chloroimidazo[2,1-b]thiazole

: 1257079-01-8
4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 4 h / 140 °C

1.2: pH ~ 10

2.1: 1-methyl-pyrrolidin-2-one / 60 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 38 h / 95 °C

4.1: acetic acid / 0.17 h / 60 °C

4.2: 60 °C

4.3: pH ~ 7

5.1: trichlorophosphate / 5 h / 80 °C

5.2: pH ~ 11 / Cooling with ice

6.1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 72 h / 75 °C

6.2: pH ~ 13

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sulfuric acid; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; isopropyl alcohol;