6-Chloroimidazo[2,1-b]thiazole

Base Information

• Chemical Name: 6-Chloroimidazo[2,1-b]thiazole
• CAS No.: 23576-81-0
• Molecular Formula: C5H3ClN2S
• Molecular Weight: 158.61
• Hs Code.: 2934100090
• European Community (EC) Number: 673-079-8
• DSSTox Substance ID: DTXSID90352242
• Wikidata: Q82129275
• Mol file: 23576-81-0.mol

Synonyms:6-Chloroimidazo[2,1-b]thiazole;23576-81-0;6-chloroimidazo[2,1-b][1,3]thiazole;Imidazo[2,1-b]thiazole, 6-chloro-;MFCD00173802;6-chloroimidazole[2,1-b][1,3]thiazole;6-chloranylimidazo[2,1-b][1,3]thiazole;Imidazo[2,1-b]thiazole,6-chloro-;SCHEMBL1879954;DTXSID90352242;CHEBI:194634;HMS1787P13;YAA57681;STL581192;6-chloro-4H-imidazo[2,1-b]thiazole;AKOS001058273;AM20090253;CS-0077636;FT-0621070;6-Chloro-imidazo(2,1-b)thiazole, AldrichCPR;5D-154;A816776;J-518617;Z56969335;F3284-0665;2I3

Chemical Property of 6-Chloroimidazo[2,1-b]thiazole

Chemical Property:

• Melting Point: 85 °C
• Refractive Index: 1.78
• PKA: 3.76±0.40(Predicted)
• PSA: 45.54000
• Density: 1.7±0.1 g/cm³
• LogP: 2.04920
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 157.9705470
• Heavy Atom Count: 9
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

6-Chloroimidazo[2,1-b][1,3]thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC2=NC(=CN21)Cl

Technology Process of 6-Chloroimidazo[2,1-b]thiazole

There total 1 articles about 6-Chloroimidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-chloroimidazo[2,1-b]thiazole (23576-81-0)

Guidance literature:

2-Imino-3-thiazolinessigsaeure, POCl3;

Reference yield: 70.0%

6-chloroimidazo[2,1-b]thiazole (23576-81-0) + Bromodiphenylphosphin (1079-65-8) → 6-chloro-5-diphenylphosphanyl-imidazo[2,1-b]thiazole

Guidance literature:

With triethylamine; In pyridine; at 20 ℃; for 24h;

DOI:10.1002/hc.20166

Reference yield: 62.0%

6-chloroimidazo[2,1-b]thiazole (23576-81-0) → 6-chloroimidazo[2,1-b][1,3]thiazol-5-ylsulfonyl chloride (150020-64-7)

Guidance literature:

With chlorosulfonic acid; at 120 ℃; for 2h;

Downstream raw materials:

6-chloroimidazo[2,1-b][1,3]thiazol-5-ylsulfonyl chloride

6-Chlorimidazo<2,1-b>thiazol-5-aldoxim

5-cyano-6-chloroimidazo<2,1-b>thiazole

6-chloro-imidazo-[2,1-b]thiazole-5-carbaldehyde