(4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

Base Information

Chemical Name:(4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one
CAS No.:1312602-64-4
Molecular Formula:C₁₈H₁₉NO₂
Molecular Weight:281.354
Hs Code.:

Synonyms:(4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

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Chemical Property of (4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

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Technology Process of (4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

There total 18 articles about (4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1312602-72-4
C₂₅H₂₅NO₂

: 1312602-64-4
(4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen;
DOI:10.1016/j.cclet.2011.01.026

Reference yield: 88.0%

: 1448603-01-7
(R)-N-methyl-3-phenyl-3-((2S,3S)-3-phenyloxiran-2-yl)propanamide

: 1312602-64-4
(4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 45 ℃;
DOI:10.1002/cjoc.201201187

Reference yield:

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 1312602-64-4
(4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethylmagnesium bromide / isopropyl alcohol; dichloromethane; tetrahydrofuran / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

2.2: 20 °C

3.1: diazomethyl-trimethyl-silane / benzene

4.1: hydrogenchloride / tetrahydrofuran; water / 20 °C

5.1: dichloromethane / 20 °C

6.1: zinc(II) tetrahydroborate / tetrahydrofuran / -78 °C

7.1: dmap; pyridine / dichloromethane / 20 °C

8.1: zinc; acetic acid / water / 90 °C

9.1: dmap; pyridine / dichloromethane

10.1: tri-n-butyl-tin hydride; triethyl borane / toluene / 20 °C

10.2: 20 °C

With pyridine; hydrogenchloride; dmap; zinc(II) tetrahydroborate; triethyl borane; ethylmagnesium bromide; tri-n-butyl-tin hydride; Dess-Martin periodane; acetic acid; zinc; diazomethyl-trimethyl-silane; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; benzene;
DOI:10.1055/s-0034-1379485