3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone

Base Information

Chemical Name:3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone
CAS No.:22280-88-2
Molecular Formula:C₁₅H₁₀BrClN₂O
Molecular Weight:349.614
Hs Code.:
DSSTox Substance ID:DTXSID901208632

Synonyms:3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone;DTXSID901208632;22280-88-2

Suppliers and Price of 3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:347.96650
Heavy Atom Count:20
Complexity:407

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)N(C(=N2)CCl)C3=CC=C(C=C3)Br

Technology Process of 3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone

There total 4 articles about 3-(4-Bromophenyl)-2-(chloromethyl)-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 106-40-1
4-bromo-aniline

: 14422-49-2
2-chloroacetamidobenzoic acid

: 22280-88-2
3-(p-bromophenyl)-2-chloromethyl-4(3H)-quinazolinone

Guidance literature:: With phosphorus trichloride; In toluene; for 3h; Heating;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 22280-88-2
3-(p-bromophenyl)-2-chloromethyl-4(3H)-quinazolinone

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 3 h / Reflux

2: trichlorophosphate / 3 h / 115 °C

With trichlorophosphate; In benzene;
DOI:10.1016/j.ejmech.2017.03.052

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 22280-88-2
3-(p-bromophenyl)-2-chloromethyl-4(3H)-quinazolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / dioxane / 24 h

2: 75 percent / PCl₃ / toluene / 3 h / Heating

With phosphorus trichloride; In 1,4-dioxane; toluene; 1: Acylation / 2: Condensation;