2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine

Base Information

• Chemical Name: 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine
• CAS No.: 100112-55-8
• Molecular Formula: C₂₇H₃₁NO₃
• Molecular Weight: 419.532
• Mol file: 100112-55-8.mol

Synonyms:2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine

Chemical Property of 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine

There total 4 articles about 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

6-(3,4-Bis-benzyloxy-phenyl)-4-isopropyl-morpholin-3-one (100112-51-4) → 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine (100112-55-8)

Guidance literature:

With lithium aluminium deuteride; In diethyl ether; for 8h; Heating;

DOI:10.1021/jm00155a025

Reference yield:

1-<3,4-bis-(benzyloxy)phenyl>-2-(isopropulamino)ethanol (100112-47-8) → 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine (100112-55-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CHCl₃ / 4 h / Ambient temperature

2: KOH / ethanol / 30 h / Ambient temperature

3: 39 percent / LiAlD₄ / diethyl ether / 8 h / Heating

With potassium hydroxide; lithium aluminium deuteride; triethylamine; In diethyl ether; ethanol; chloroform;

DOI:10.1021/jm00155a025

Reference yield:

N-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-chloro-N-isopropyl-acetamide (100112-49-0) → 2-<3,4-bis(benzyloxy)phenyl>-4-isopropyl-5,5-dideuteriomorpholine (100112-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol / 30 h / Ambient temperature

2: 39 percent / LiAlD₄ / diethyl ether / 8 h / Heating

With potassium hydroxide; lithium aluminium deuteride; In diethyl ether; ethanol;

DOI:10.1021/jm00155a025

upstream raw materials:

6-(3,4-Bis-benzyloxy-phenyl)-4-isopropyl-morpholin-3-one

1-<3,4-bis-(benzyloxy)phenyl>-2-(isopropulamino)ethanol

N-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-chloro-N-isopropyl-acetamide

3,4-bis-(benzyloxy)-ω-(isopropulamino)acetophenone hydrobromide