diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

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Chemical Name:diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate
CAS No.:288380-05-2
Molecular Formula:C₅₀H₄₀N₆O₅S₄
Molecular Weight:933.169
Hs Code.:

Synonyms:diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

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Chemical Property of diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

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Technology Process of diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

There total 4 articles about diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 163009-35-6
7β-acylcephem

: thioacetic acid S-(pyridin-4-ylsulfanylmethyl) ester

: 288380-05-2
diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

Guidance literature:: thioacetic acid S-(pyridin-4-ylsulfanylmethyl) ester; With sodium methylate; In tetrahydrofuran; methanol;

7β-acylcephem; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00021-3

Reference yield:

: 128438-01-7
(Z)-2-(2-aminothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid

: 288380-05-2
diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: BSA; MsCl; K₂CO₃ / N,N-dimethyl-acetamide

2.1: sodium methoxide / methanol; tetrahydrofuran

2.2: 80 percent / methanol; tetrahydrofuran; dimethylformamide

With benzenesulfonamide; sodium methylate; potassium carbonate; methanesulfonyl chloride; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; 1.1: Substitution / 2.1: thioester cleavage / 2.2: Substitution;
DOI:10.1016/S0968-0896(00)00021-3

Reference yield:

: 74704-03-3
diphenylmethyl 7β-amino-3-methanesulfonyloxy-3-cephem-4-carboxylate

: 288380-05-2
diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: BSA; MsCl; K₂CO₃ / N,N-dimethyl-acetamide

2.1: sodium methoxide / methanol; tetrahydrofuran

2.2: 80 percent / methanol; tetrahydrofuran; dimethylformamide

With benzenesulfonamide; sodium methylate; potassium carbonate; methanesulfonyl chloride; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; 1.1: Substitution / 2.1: thioester cleavage / 2.2: Substitution;
DOI:10.1016/S0968-0896(00)00021-3