1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

Base Information

Chemical Name:1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene
CAS No.:861676-03-1
Molecular Formula:C₃₄H₆₄O₄Si₂
Molecular Weight:593.051
Hs Code.:

Synonyms:1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

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Chemical Property of 1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

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Technology Process of 1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

There total 6 articles about 1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 861676-00-8
(2S,4R,5R/S,6E,8R,9R)-1-(4-methoxybenzyloxy)-9-(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-en-5-ol

: 69739-34-0
t-butyldimethylsiyl triflate

: 861676-03-1
1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/ja0504340

Reference yield:

: 861675-99-2
(2R,4S)-5-(4-methoxybenzyloxy)-2,4-dimethylpentanal

: 861676-03-1
1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / CrCl₂; NiCl₂ / dimethylsulfoxide / 48 h / 23 °C

2: 97 percent / diisopropylethylamine / CH₂Cl₂ / 2 h / 0 °C

With chromium dichloride; N-ethyl-N,N-diisopropylamine; nickel dichloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja0504340

Reference yield:

: 861675-98-1
(2R,4S)-5-(4-methoxybenzyloxy)-N-methoxy-N,2,4-trimethylpentanamide

: 861676-03-1
1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / DIBAL-H / tetrahydrofuran; toluene / 2 h / -78 °C

2: 70 percent / CrCl₂; NiCl₂ / dimethylsulfoxide / 48 h / 23 °C

3: 97 percent / diisopropylethylamine / CH₂Cl₂ / 2 h / 0 °C

With chromium dichloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; nickel dichloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja0504340