861676-00-8

Upstream product

• 343782-84-3 (2R,4S)-5-hydroxy-N-methoxy-N,2,4-trimethylpentanamide 
• 74034-73-4 (3R,5S)-3,5-dimethyltetrahydro-2H-pyran-2-one 
• 861675-98-1 (2R,4S)-5-(4-methoxybenzyloxy)-N-methoxy-N,2,4-trimethylpentanamide 
• 861675-99-2 (2R,4S)-5-(4-methoxybenzyloxy)-2,4-dimethylpentanal 
• 216493-86-6 tert-Butyl-((E)-(1R,2R)-1-ethyl-4-iodo-2-methyl-but-3-enyloxy)-dimethyl-silane 

Downstream Products

• 861676-06-4 R-3-((2R,3S,4S,6R,7R/S,8E,10R,11R)-7,11-bis(tert-butyldimetylsilyloxy)-3-hydroxy-2,4,6,10-tetramethyltridec-8-enoyl)-4-benzyloxazolidin-2-one 
• 861676-03-1 1-(((2S,4R,5R/S,6E,8R,9R)-5,9-bis(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-enyloxy)methyl)-4-methoxybenzene 
• 861676-01-9 (2S,4R,6E,8R,9R)-1-(4-methoxybenzyloxy)-9-(tert-butyldimetylsilyloxy)-2,4,8-trimethylundec-6-en-5-one 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide

The polyketide synthase-derived pikromycin thioesterase (Pik TE) is unique in its ability to catalyze the cyclization of 12- and 14-membered macrolactones. In this investigation, the total synthesis of the natural hexaketide chain elongation intermediate