2-Hydrazinyl-3-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2-Hydrazinyl-3-(trifluoromethyl)pyridine
• CAS No.: 89570-83-2
• Molecular Formula: C6H6F3N3
• Molecular Weight: 177.129
• Hs Code.: 2933990090
• European Community (EC) Number: 640-276-5,670-805-5
• DSSTox Substance ID: DTXSID70380649
• Wikidata: Q72512805
• Mol file: 89570-83-2.mol

Synonyms:89570-83-2;2-hydrazinyl-3-(trifluoromethyl)pyridine;(3-Trifluoromethylpyrid-2-yl)hydrazine;[3-(trifluoromethyl)pyridin-2-yl]hydrazine;3-(Trifluoromethyl)pyrid-2-ylhydrazine;2-hydrazino-3-(trifluoromethyl)pyridine;1-(3-(trifluoromethyl)pyridin-2-yl)hydrazine;3-(Trifluoromethyl)pyridine-2-hydrazine;(3-Trifluoromethyl-pyridin-2-yl)-hydrazine;SCHEMBL358590;2(1H)-Pyridinone, 3-(trifluoromethyl)-, hydrazone;DTXSID70380649;3-trifluoromethyl-2-hydrazinopyridine;MFCD01320804;2-Hydrazino-3-(trifluormethyl)pyridin;AKOS000148658;SB52406;AC-29125;AM101522;BL010283;BP-13307;CS-0094721;FT-0642128;EN300-36763;12P-663;J-509578;F2173-0092

Chemical Property of 2-Hydrazinyl-3-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.0221mmHg at 25°C
• Refractive Index: 1.528
• Boiling Point: 250.1 °C at 760 mmHg
• PKA: 8.81±0.70(Predicted)
• Flash Point: 105 °C
• PSA: 50.94000
• Density: 1.442g/cm³
• LogP: 2.15930
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 177.05138169
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-(Trifluoromethyl)pyridin-2-yl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)NN)C(F)(F)F

Technology Process of 2-Hydrazinyl-3-(trifluoromethyl)pyridine

There total 2 articles about 2-Hydrazinyl-3-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-3-trifluoromethyl-pyridine (65753-47-1) → 2-hydrazinyl-3-(trifluoromethyl)pyridine (89570-83-2)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.tetlet.2020.151844

Reference yield: 53.0%

2-bromo-3-(trifluoromethyl)-pyridine (175205-82-0) → 2-hydrazinyl-3-(trifluoromethyl)pyridine (89570-83-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 105 ℃; for 29h;

DOI:10.1016/j.ejmech.2021.113232

Reference yield: 59.0%

phthalic anhydride (85-44-9) + propionaldehyde (123-38-6) + 2-hydrazinyl-3-(trifluoromethyl)pyridine (89570-83-2) → 2-(3-ethyl-8-(trifluoromethyl)-2,3-dihydro[1,2,4]triazolo[4,3-a]pyridine-2-carbonyl)benzoic acid (1610342-83-0)

Guidance literature:

In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

DOI:10.1021/jo500723d

upstream raw materials:

2-chloro-3-trifluoromethyl-pyridine

2-bromo-3-(trifluoromethyl)-pyridine

Downstream raw materials:

3-(3-ethylphenyl)-1-(3-trifluoromethylpyridin-2-yl)-1H-pyrazol-5-amine

1-(3-(trifluoromethyl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid

(E)-N-(3-isopropyl-9-(trifluoromethyl)-2H-pyrido[2,1-c]-[1,2,4]triazin-4(3H)-ylidene)-1-phenylmethanamine

2-(3-(2-(methylthio)ethyl)-8-(trifluoromethyl)-2,3-dihydro[1,2,4]triazolo[4,3-a]pyridine-2-carbonyl)benzoic acid

Refernces

• 1、 Liu, Lingfeng,Qiao, Chunhua,Shen, Bei,Xu, Yiwen. "Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source". supporting information. . Retrieved 2020/04/01.
• 2、 Evans, Richard A.,Wentrup, Curt. "Trifluoromethyl-substituted Dehydrodiazepines and Cyanopyrroles from Azido-/Tetrazolo-pyridines". . p. 1062 - 1064. Retrieved 2007/10/02.