175205-82-0

Basic information

• Product Name: 2-Bromo-3-trifluoromethylpyridine
• Synonyms: 2-Bromo-3-trifluoromethylpyridine 2-Bromo-3-(trifluoromethyl)pyridine;BUTTPARK 27\06-85;PYRIDINE, 2-BROMO-3-(TRIFLUOROMETHYL)-;2-Bromo-3-(trifluoromethyl)pyridine 98%;2-Bromo-3-(trifluoromethyl)pyridine98%;16189 2-BROMO-3-TRIFLUOROMETHYLPYRIDINE;16189;Bromotrifluoromethylpyridine 23()---
• CAS NO: 175205-82-0
• Molecular Formula: C₆H₃BrF₃N
• Molecular Weight: 225.99
• Product Categories: blocks;Bromides;FluoroCompounds;Pyridines;Halides;Pyridine;Halogenated;Organohalides;Bromopyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Fluorine series
• Mol File: 175205-82-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 37-41 °C
• Boiling Point: 76°C 8mm
• Flash Point: 84 °F
• Appearance: Light yellow cryst
• Density: 1.707 g/cm³
• Vapor Pressure: 0.000858mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1?+-.0.10(Predicted)
• Water Solubility: Insoluble in water
• CAS DataBase Reference: 2-Bromo-3-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-trifluoromethylpyridine(175205-82-0)
• EPA Substance Registry System: 2-Bromo-3-trifluoromethylpyridine(175205-82-0)

Safety Data

• Hazard Codes: F,T,Xi
• Statements: 11-25-37/38-41-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2926 4.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 175205-82-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

InChI:InChI=1/C10H6ClF3N2O/c11-5-8-15-9(17-16-8)6-1-3-7(4-2-6)10(12,13)14/h1-4H,5H2

Upstream product

• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 

Downstream Products

• 1403396-38-2 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-(1-{4-[3-(trifluoromethyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 89570-83-2 2-hydrazinyl-3-(trifluoromethyl)pyridine 
• 952182-76-2 ethyl 3-(trifluoromethyl)picolinate 
• 749257-78-1 1-[3-(trifluoromethyl)pyridin-2-yl]ethane-1-one 
• 170502-06-4 2-Benzyl-3-trifluoromethylpyridine 
• 1643489-24-0 1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)-oxy)phenyl)pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids

As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).