5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol

Base Information

• Chemical Name: 5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol
• CAS No.: 158719-79-0
• Molecular Formula: C₁₉H₁₇N₃O₄S₂
• Molecular Weight: 415.494
• Mol file: 158719-79-0.mol

Synonyms:5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol

Chemical Property of 5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol

There total 1 articles about 5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.6%

1-bromo-4,5-methylenedioxy-2-nitrobenzene (7748-58-5) + 2-amino-benzenethiol (137-07-5) → 2-(6-Nitro-benzo[1,3]dioxol-5-ylsulfanyl)-phenylamine (67851-24-5) + 5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol (158719-79-0)

Guidance literature:

With sodium methylate; In dimethyl sulfoxide; at 130 ℃; for 0.5h;

DOI:10.1248/cpb.42.500

Reference yield:

5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol (158719-79-0) → 2-Diethylamino-N-(2-{4-[2-(2-diethylamino-acetylamino)-phenylsulfanylmethoxy]-5-hydroxy-2-nitro-phenylsulfanyl}-phenyl)-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 4 h / Ambient temperature

2: toluene / 2 h / Heating

In toluene; benzene;

DOI:10.1248/cpb.42.500

Reference yield:

chloroacetyl chloride (79-04-9) + 5-(2-Amino-phenylsulfanyl)-2-(2-amino-phenylsulfanylmethoxy)-4-nitro-phenol (158719-79-0) → 2-Chloro-N-(2-{4-[2-(2-chloro-acetylamino)-phenylsulfanylmethoxy]-5-hydroxy-2-nitro-phenylsulfanyl}-phenyl)-acetamide (1026606-46-1)

Guidance literature:

In benzene; for 4h; Ambient temperature;

DOI:10.1248/cpb.42.500

upstream raw materials:

1-bromo-4,5-methylenedioxy-2-nitrobenzene

2-amino-benzenethiol

Downstream raw materials:

2-Chloro-N-(2-{4-[2-(2-chloro-acetylamino)-phenylsulfanylmethoxy]-5-hydroxy-2-nitro-phenylsulfanyl}-phenyl)-acetamide