Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

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Chemical Name:Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester
CAS No.:240821-18-5
Molecular Formula:C₂₆H₃₈O₉
Molecular Weight:494.582
Hs Code.:

Synonyms:Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

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Chemical Property of Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

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Technology Process of Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

There total 26 articles about Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 240821-14-1
Acetic acid (E)-(1S,4R)-1-[(1S,2S,3R)-1-acetoxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-3-methyl-butyl]-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-pent-2-enyl ester

: 240821-18-5
Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at -10 ℃;
DOI:10.1055/s-1999-2730

Reference yield: 93.0%

: 240821-16-3
(2R,3E,5S,6S,7S,8R)-5-acetoxy-6-acetoxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonene-1,9-diol

: 240821-18-5
Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at -10 ℃; for 0.583333h;
DOI:10.1248/cpb.47.1288

Reference yield:

: 240821-06-1
(2R,3E,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one

: 240821-18-5
Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / PPTS / ethanol / 6 h / 50 - 55 °C

2: 96 percent / Zn(BH₄)2 / diethyl ether / 7 h / 0 °C

3: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 10.5 h / 0 °C

4: 100 percent / TBAF; AcOH / tetrahydrofuran / 144 h / 20 °C

5: 93 percent / DDQ / CH₂Cl₂ / 0.58 h / -10 °C

With dmap; zinc(II) tetrahydroborate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 1: Hydrolysis / 2: Hydrogenolysis / 3: Acetylation / 4: desilylation / 5: Cyclization;
DOI:10.1248/cpb.47.1288