1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

Base Information

Chemical Name:1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide
CAS No.:1621065-33-5
Molecular Formula:C₁₉H₂₁N₃O₃S
Molecular Weight:371.46
Hs Code.:

Synonyms:1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

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Chemical Property of 1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

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Technology Process of 1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

There total 4 articles about 1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 135276-91-4
1,2,3,4-tetrahydropyrimido<1,2-c><1,2,4>benzothiadiazine 6,6-dioxide

: 73735-36-1
methanesulfonic acid-2-(4-methoxyphenyl)ethyl ester

: 1621065-33-5
1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

Guidance literature:: 1,2,3,4-tetrahydropyrimido<1,2-c><1,2,4>benzothiadiazine 6,6-dioxide; With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;

methanesulfonic acid-2-(4-methoxyphenyl)ethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 24h; Inert atmosphere;
DOI:10.1055/s-0033-1340249

Reference yield:

: 702-23-8
2-(4-Methoxyphenyl)ethanol

: 1621065-33-5
1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 8 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

2.2: 24 h / 60 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.6b00847

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1621065-33-5
1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b]1,2,4-benzothiadiazine 6,6-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C

2.1: tin(ll) chloride; hydrogenchloride / ethanol / 12 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 60 °C / Inert atmosphere

3.2: 24 h / 60 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.6b00847