73735-36-1

Basic information

• Product Name: 2-(4-methoxyphenyl)ethyl methanesulfonate
• CAS NO: 73735-36-1
• Molecular Formula: C₁₀H₁₄O₄S
• Molecular Weight: 230.2808
• Mol File: 73735-36-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 397.8°C at 760 mmHg
• Flash Point: 194.4°C
• Density: 1.211g/cm³
• Vapor Pressure: 3.54E-06mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 2-(4-methoxyphenyl)ethyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)ethyl methanesulfonate(73735-36-1)
• EPA Substance Registry System: 2-(4-methoxyphenyl)ethyl methanesulfonate(73735-36-1)

Safety Data

• Hazardous Substances Data: 73735-36-1(Hazardous Substances Data)

Usage

Molecular weight

214.28 g/mol

Functional group

Methanesulfonate

Substituents

2-(4-methoxyphenyl)ethyl group

Usage

Reagent in organic synthesis, methanesulfonate leaving group in the preparation of various compounds

Reactions

Nucleophilic substitution, elimination reactions

Applications

Synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Safety

Handle with care, follow proper safety protocols to avoid hazards.

Upstream product

• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 124-63-0 methanesulfonyl chloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 75970-98-8 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-{1-[2-(4-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73755-88-1 3-<(4-fluorophenyl)methyl>-N-<1-<2-(4-methoxyphenyl)ethyl>-4-piperidinyl>-3H-imidazo<4,5-b>pyridin-2-amine 
• 68844-77-9 astemizole 

Relevant articles and documents

CATALYTIC SYSTEMS FOR STEREOSELECTIVE SYNTHESIS OF CHIRAL AMINES BY ENANTIODIVERGENT RADICAL C-H AMINATION

In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp3)-H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

A new compound and its preparation method (by machine translation)

The invention provides a new compound and a preparation method thereof. The compound is a new impurity of venlafaxine, and particularly is (+/-)-1-{2-[(4-methoxy phenyl ethyl) (methyl) amino]-1-(4-methoxy phenyl) ethyl} cyclohexanol. The compound and the preparation method thereof provide support for more accurate control of impurities in venlafaxine and acquisition of venlafaxine which is more safe and reliable and has a definite curative effect.

HETEROCYCLIC CARBOXYLIC ACIDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R9, B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.