acetonyl methoxatin

Base Information

• Chemical Name: acetonyl methoxatin
• CAS No.: 73030-04-3
• Molecular Formula: C₁₇H₁₂N₂O₉
• Molecular Weight: 388.29
• Mol file: 73030-04-3.mol

Synonyms:acetonyl methoxatin

Chemical Property of acetonyl methoxatin

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1012.3°C at 760 mmHg
• Flash Point: 566°C
• PSA: 194.95000
• Density: 1.778g/cm³
• LogP: 0.53430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of acetonyl methoxatin

There total 18 articles about acetonyl methoxatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

pyrroloquinoline quinone (72909-34-3) + acetone (67-64-1) → 4,5-dihydro-5-hydroxy-4-oxo-5-(2-oxopropyl)-1H-pyrrolo<2,3-f>quinoline-2,7,9-tricarboxylic acid (73030-04-3)

Guidance literature:

With ammonium hydroxide; for 0.5h; Ambient temperature;

DOI:10.1021/jo00136a002

Reference yield:

trimethyl 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate (74447-88-4) → 4,5-dihydro-5-hydroxy-4-oxo-5-(2-oxopropyl)-1H-pyrrolo<2,3-f>quinoline-2,7,9-tricarboxylic acid (73030-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / LiOH, H₂O / tetrahydrofuran / 5 h / Ambient temperature

2: NH₄OH / H₂O / 0.5 h / Ambient temperature

With lithium hydroxide; ammonium hydroxide; water; In tetrahydrofuran; water;

DOI:10.1021/jo00334a053

Reference yield:

4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid disodium salt + acetone (67-64-1) → 4,5-dihydro-5-hydroxy-4-oxo-5-(2-oxopropyl)-1H-pyrrolo<2,3-f>quinoline-2,7,9-tricarboxylic acid (73030-04-3)

Guidance literature:

With sodium hydroxide; In water; pH=9;

upstream raw materials:

pyrroloquinoline quinone

acetone

4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester

3-Amino-4,5-dihydroxy-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid 2-ethyl ester 7,9-dimethyl ester

Refernces

• 1、 Hendrickson, James B.,Vries, Johannes G., de. "Total Synthesis of the Novel Coenzyme Methoxatin". . p. 1688 - 1695. Retrieved 2007/10/02.
• 2、 Hendrickson, James B.,deVries, Johannes G.. "A Convergent Total Synthesis of Methoxatin". . p. 1148 - 1150. Retrieved 2007/10/02.