Technology Process of (3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt
There total 7 articles about (3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran; 1,4-dioxane;
at 50 - 55 ℃;
for 1.5h;
DOI:10.1248/cpb.32.1303
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / triethylamine / dimethylformamide / 1) 0 deg C, 30 min; 2) RT, 1 h
3: H2 / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature
4: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature
5: 97 percent / 1) potassium fluoride; 2) acetic acid / methanol / 0.25 h / 0 °C
6: 98 percent / tetrahydrofuran; dioxane / 1.5 h / 50 - 55 °C
With
potassium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.1303
- Guidance literature:
-
Multi-step reaction with 5 steps
2: H2 / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature
3: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature
4: 97 percent / 1) potassium fluoride; 2) acetic acid / methanol / 0.25 h / 0 °C
5: 98 percent / tetrahydrofuran; dioxane / 1.5 h / 50 - 55 °C
With
potassium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1248/cpb.32.1303
