8-HYDROXY MIRTAZAPINE

Base Information

• Chemical Name: 8-HYDROXY MIRTAZAPINE
• CAS No.: 102335-57-9
• Molecular Formula: C₁₇H₁₉N₃O
• Molecular Weight: 281.357
• Mol file: 102335-57-9.mol

Synonyms:8-Hydroxy-6-azamianserin;8-Hydroxymirtazapine

Chemical Property of 8-HYDROXY MIRTAZAPINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >242°C (dec.)
• Boiling Point: 559.604°C at 760 mmHg
• Flash Point: 292.238°C
• PSA: 39.60000
• Density: 1.318g/cm³
• LogP: 2.18740
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

98%Min ^*data from raw suppliers

8-Hydroxy Mirtazapine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Hydroxy Mirtazapine is used in the synthesis of Mirtazapine (M365000) metabolite. Labelled metabolite of Mirtazapine (M365000). Labelled analog of the main metabolite of Mirtazapine (M365000).

Technology Process of 8-HYDROXY MIRTAZAPINE

There total 2 articles about 8-HYDROXY MIRTAZAPINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Mirtazapine (85650-52-8,61337-67-5,61364-37-2) → 1,2,3,4,10,14b-hexahydro-2-methylpyrazino<2,1-a>pyrido<2,3-c><2>benzazepin-8-ol (102335-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / bromine / acetic acid / 4 h / Ambient temperature

2: 1) BuLi, 2) nitrobenzene / 1) THF, hexane, -60 deg C, 45 mini580, 2) THF, hexane, -196 to -60 deg C and 3.5 h at -60 deg C

With n-butyllithium; bromine; nitrobenzene; In acetic acid;

DOI:10.1002/recl.19851041004

Reference yield:

1,2,3,4,10,14b-hexahydro-8-bromo-2-methyl-pyrazino<2,1-a>pyrido<2,3-c><2>benzazepine (61337-86-8) → 1,2,3,4,10,14b-hexahydro-2-methylpyrazino<2,1-a>pyrido<2,3-c><2>benzazepin-8-ol (102335-57-9)

Guidance literature:

With n-butyllithium; nitrobenzene; Yield given. Multistep reaction; 1) THF, hexane, -60 deg C, 45 mini580, 2) THF, hexane, -196 to -60 deg C and 3.5 h at -60 deg C;

DOI:10.1002/recl.19851041004

upstream raw materials:

1,2,3,4,10,14b-hexahydro-8-bromo-2-methyl-pyrazino<2,1-a>pyrido<2,3-c><2>benzazepine

Mirtazapine

Refernces