5-TRIFLUOROMETHYL-1,3,4-OXADIAZOL-2-YLAMINE

Base Information

• Chemical Name: 5-TRIFLUOROMETHYL-1,3,4-OXADIAZOL-2-YLAMINE
• CAS No.: 768-29-6
• Molecular Formula: C3H2F3N3O
• Molecular Weight: 153.064
• Hs Code.: 2934999090
• Mol file: 768-29-6.mol

Synonyms:1,3,4-Oxadiazole,2-amino-5-(trifluoromethyl)- (6CI,8CI);(5-Trifluoromethyl-1,3,4-oxadiazol-2-yl)amine;5-(Trifluoromethyl)-1,3,4-oxadiazol-2-amine;2-Amino-5-trifluoromethyl-1,3,4-oxadiazole;

Chemical Property of 5-TRIFLUOROMETHYL-1,3,4-OXADIAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 4.89mmHg at 25°C
• Melting Point: 155-160°C
• Refractive Index: 1.42
• Boiling Point: 145.3 °C at 760 mmHg
• PKA: -2.91±0.13(Predicted)
• Flash Point: 41.7 °C
• PSA: 64.94000
• Density: 1.62 g/cm³
• LogP: 1.25180
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(Trifluoromethyl)-1,3,4-oxadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-TRIFLUOROMETHYL-1,3,4-OXADIAZOL-2-YLAMINE

There total 1 articles about 5-TRIFLUOROMETHYL-1,3,4-OXADIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromocyane (506-68-3) + 2,2,2-trifluoroacetohydrazide (1538-08-5) → 5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine (768-29-6)

Guidance literature:

Reference yield: 57.0%

4-phenyloxybutanoic acid (6303-58-8) + 5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine (768-29-6) → 4-phenoxy-N-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)butanamide

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 45 ℃; for 16h;

DOI:10.1021/acs.jmedchem.9b00462

Reference yield: 32.0%

3-(N-(4-chlorophenyl)sulfamoyl)benzoic acid (147410-78-4) + 5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine (768-29-6) → 3-(N-(4-chlorophenyl)sulfamoyl)-N-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)benzamide (1586822-42-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2014.02.003

upstream raw materials:

bromocyane

2,2,2-trifluoroacetohydrazide

Downstream raw materials:

3-(N-(4-chlorophenyl)sulfamoyl)-N-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)benzamide