1538-08-5

Basic information

• Product Name: TRIFLUOROACETIC ACID HYDRAZIDE
• Synonyms: TRIFLUOROACETIC ACID HYDRAZIDE;2,2,2-Trifluoroacetohydrazide;Trifluoroacetyl Hydrazide;Acetic acid, 2,2,2-trifluoro-, hydrazide;2,2,2-trifluoroAcetic acid hydrazide
• CAS NO: 1538-08-5
• Molecular Formula: C₂H₃F₃N₂O
• Molecular Weight: 128.05
• Mol File: 1538-08-5.mol

Chemical Properties

• Melting Point: 111 °C
• Boiling Point: 192.3 °C at 760 mmHg
• Flash Point: 70.1 °C
• Appearance: /
• Density: 1.462 g/cm³
• Vapor Pressure: 0.493mmHg at 25°C
• Refractive Index: 1.351
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.47±0.20(Predicted)
• CAS DataBase Reference: TRIFLUOROACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIFLUOROACETIC ACID HYDRAZIDE(1538-08-5)
• EPA Substance Registry System: TRIFLUOROACETIC ACID HYDRAZIDE(1538-08-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1538-08-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
TRIFLUOROACETIC ACID HYDRAZIDE is used as a reagent for the preparation of heterocyclic compounds, which are important in the development of pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique trifluoroacetyl group contributes to the formation of diverse molecular structures with potential applications in various industries.
Used in Mass Spectrometry:
In the field of analytical chemistry, TRIFLUOROACETIC ACID HYDRAZIDE serves as a derivatization reagent in mass spectrometry. It is utilized for the analysis of biomolecules, enhancing the detection and characterization of these complex substances, which is crucial for research in biology, medicine, and related fields.
Used in Pharmaceutical Production:
TRIFLUOROACETIC ACID HYDRAZIDE is employed in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its role in the production process highlights its importance in the healthcare sector, despite the need for careful handling due to its toxic nature.
Used in Agrochemical Production:
Similarly, in the agrochemical industry, TRIFLUOROACETIC ACID HYDRAZIDE is used in the manufacturing of pesticides and other crop protection agents. Its application in this field underscores its versatility and the broad impact of its chemical properties on agriculture and food security.

InChI:InChI=1/C2H3F3N2O/c3-2(4,5)1(8)7-6/h6H2,(H,7,8)

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 220294-74-6 N-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2,2,2-trifluoro-acetamide 
• 76-05-1 trifluoroacetic acid 
• 302-01-2 hydrazine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 54047-14-2 N-phenyl-2-(trifluoroacetyl)hydrazinecarbothioamide 
• 216504-41-5 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine 
• 762240-99-3 N'-(2-chloroacetyl)trifluoroacetohydrazide 
• 60406-75-9 3-(trifluoromethyl)-1H-1,2,4- triazole 
• 1186210-40-1 C₁₇H₁₂F₃N₃O₃S 
• 219508-27-7 5-trifluoromethyl-3-(2′-pyridyl)-2H-1,2,4-triazole 
• 667-35-6 1,2-bis(trifluoroacetyl)hydrazine 
• 1062197-44-7 2-(Trifluoromethyl)-7-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-c]pyrimidin-5-ol 
• 1062197-42-5 7-(2,4-dichlorophenyl)-2-(trifluoromethyl)[1,2,4]triazolo[1,5-c]pyrimidin-5-ol 
• 1190863-04-7 3-(3-iodo-4-methylphenyl)-5-(trifluoromethyl)-4H-1,2,4-triazole 
• 1140495-97-1 (R)-tert-butyl 2-[4-(4-chlorobenzyl)-5-(trifluoromethyl)-4H-1,2,4-triazole-3-yl]pyrrolidine-1-carboxylate 
• 868670-05-7 1-benzyl-4-[3-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl]piperidine 
• 871477-12-2 C₁₂H₉ClF₃N₃S 
• 257885-38-4 2-[N'-(2,2,2-Trifluoro-acetyl)-hydrazinocarbonyl]-benzoic acid 

Relevant articles and documents

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On the basis of the results of frontier orbital considerations, 4-substituted-2′-pyridyltriazoles were designed to serve as ancillary ligands in 2-phenylpyridine main ligand containing heteroleptic iridium(III) complexes that display deep blue phosphorescence emission. The iridium(III) complexes, Ir1-Ir7, prepared using the new ancillary ligands, were found to display structured, highly quantum efficient (Φp = 0.20-0.42) phosphorescence with emission maxima in the blue to deep blue 448-456 nm at room temperature. In accord with predictions based on frontier orbital considerations, the complexes were observed to have emission properties that are dependent on the electronic nature of substituents at the C-4 position of the pyridine moiety of the ancillary ligand. Importantly, placement of an electron-donating methyl group at C-4′ of the pyridine ring of the 5-(pyridine-2′-yl)-3-trifluoromethyl-1,2,4-triazole ancillary ligand leads to an iridium(III) complex that displays a deep blue phosphorescence emission maximum at 448 nm in both the liquid and film states at room temperature. Finally, an OLED device, constructed using an Ir-complex containing the optimized ancillary ligand as the dopant, was found to emit deep blue color with a CIE of 0.15, 0.18, which is close to the perfect goal of 0.15, 0.15.