(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester
CAS No.:246869-62-5
Molecular Formula:C₄₂H₄₇N₃O₆
Molecular Weight:689.852
Hs Code.:

Synonyms:(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

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Chemical Property of (S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

There total 5 articles about (S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 111934-23-7
MeNH-L-Lys(ε-Cbz)-CO2Me

: trans-1-(3,3-diphenylpropionyl)-3-phenyl-pyrrolidine-2-carboxylic acid

: 246869-62-5
(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

: 246869-66-9
(S)-6-Benzyloxycarbonylamino-2-{[(2S,3R)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

Guidance literature:: With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(99)00561-X

Reference yield:

: 37089-77-3
3,3-diphenylpropanoyl chloride

: 246869-62-5
(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / aq. Na₂CO₃ / 12 h / 0 - 20 °C

2: 48 percent / N,N-diisopropylethylamine; bromotris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / 20 °C

With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Acylation / 2: Condensation;
DOI:10.1016/S0040-4020(99)00561-X

Reference yield:

: 246869-32-9
3-Phenyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 246869-62-5
(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-methyl-amino}-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / MeONa / methanol / 2 h / Heating

2: 75 percent / aq. HCl; AcOH / 3 h / Heating

3: 89 percent / aq. Na₂CO₃ / 12 h / 0 - 20 °C

4: 48 percent / N,N-diisopropylethylamine; bromotris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 1 h / 20 °C

With hydrogenchloride; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; sodium methylate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; 1: Hydrolysis / 2: Hydrolysis / 3: Acylation / 4: Condensation;
DOI:10.1016/S0040-4020(99)00561-X