(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

Base Information

Chemical Name:(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate
CAS No.:1381841-55-9
Molecular Formula:C₂₄H₂₈F₂N₆O₅S
Molecular Weight:550.586
Hs Code.:

(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

Synonyms:(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

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Chemical Property of (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

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Technology Process of (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

There total 19 articles about (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂F₂N₆O₅S

: 1381841-55-9
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

Guidance literature:: With iodine; In methanol; at 60 ℃; for 4h;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

: 1381841-55-9
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sodium iodide / 1,4-dioxane / 120 °C

2.1: sodium nitrite / water; acetic acid; ethyl acetate

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane

4.1: triethylamine / acetonitrile / 0.5 h / 20 °C

4.2: 2 h / 20 °C

5.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 1006614-49-8,220352-38-5,1459719-81-3
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

: 1381841-55-9
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane

2.1: triethylamine / acetonitrile / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050