tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

Base Information

Chemical Name:tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate
CAS No.:1401065-82-4
Molecular Formula:C₂₃H₂₆BrN₃O₄
Molecular Weight:488.381
Hs Code.:

Synonyms:tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

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Chemical Property of tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

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Technology Process of tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

There total 4 articles about tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1078791-16-8,403478-69-3
(S)-N-(4-bromophenyl)pyrrolidine-2-carboxamide

: 68790-38-5
2-(tert-butyloxycarbonylamino)benzoic acid

: 1401065-82-4
tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

Guidance literature:: With ethylene dichloride hydrochloride; benzotriazol-1-ol; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/c3ob41967c

Reference yield: 87.0%

: 1078791-16-8,403478-69-3
(S)-N-(4-bromophenyl)pyrrolidine-2-carboxamide

: 164226-32-8
2-(tert-butyloxycarbonyl)aminobenzyl alcohol

: 1401065-82-4
tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

Guidance literature:: With hydrogenchloride; dmap; 1,2-dichloro-ethane; In dichloromethane; for 12h;
DOI:10.1039/c2cc34533a

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1401065-82-4
tert-butyl (S)-2-(2-(4-bromophenylcarbamoyl)pyrrolidine-1-carbonyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 3 h / 20 °C

2: ethylene dichloride hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C

With ethylene dichloride hydrochloride; benzotriazol-1-ol; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1039/c3ob41967c