N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

Base Information

Chemical Name:N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide
CAS No.:1052723-05-3
Molecular Formula:C₂₅H₂₉ClN₄O₅
Molecular Weight:500.982
Hs Code.:

Synonyms:N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

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Chemical Property of N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

Chemical Property:

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Technology Process of N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

There total 6 articles about N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052723-04-2
2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

: 1003-03-8
Cyclopentamine

: 1052723-05-3
N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 1052723-41-7
(2-amino-benzylamino)-acetic acid methyl ester

: 1052723-05-3
N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,4-dioxane / 24 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 20 °C

5.1: methanol; potassium hydroxide; water / 20 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 20 °C

With methanol; triethylsilane; potassium hydroxide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1052723-42-8
(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid methyl ester

: 1052723-05-3
N-(5-chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 20 °C

4.1: methanol; potassium hydroxide; water / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 20 °C

With methanol; triethylsilane; potassium hydroxide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;