2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

Base Information

Chemical Name:2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid
CAS No.:1052723-04-2
Molecular Formula:C₂₀H₂₀ClN₃O₆
Molecular Weight:433.848
Hs Code.:

Synonyms:2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

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Chemical Property of 2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

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Technology Process of 2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

There total 6 articles about 2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052723-33-7
{1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2-oxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid methyl ester

: 1052723-04-2
2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

Guidance literature:: {1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2-oxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid methyl ester; With methanol; potassium hydroxide; water; at 20 ℃;

With hydrogenchloride; In water; pH=4;

Reference yield:

: 1052723-42-8
(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid methyl ester

: 1052723-04-2
2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 5 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 20 °C

4.1: methanol; potassium hydroxide; water / 20 °C

4.2: pH 4

With methanol; triethylsilane; potassium hydroxide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1052723-40-6
(3-methoxycarbonylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetic acid

: 1052723-04-2
2-[1-[2-(5-chloro-2,4-dimethoxyanilino)-2-oxo-ethyl]-2-oxo-4H-quinazolin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 20 °C

2.1: methanol; potassium hydroxide; water / 20 °C

2.2: pH 4

With methanol; potassium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;