6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Base Information

Chemical Name:6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide
CAS No.:1240494-14-7
Molecular Formula:C₂₀H₁₅BF₄N₂O₄S
Molecular Weight:466.221
Hs Code.:

Synonyms:6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

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Chemical Property of 6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Chemical Property:

Density:1.49±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Technology Process of 6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

There total 4 articles about 6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240494-30-7
6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

: 1240494-14-7
6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Guidance literature:: With potassium hydrogenfluoride; water; In methanol; for 1h;

Reference yield:

: 17624-07-6,92823-43-3
6-Mercapto-nicotinic acid

: 1240494-14-7
6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 12 h

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3: potassium hydrogen difluoride / water; methanol / 1 h

With potassium hydrogen difluoride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: N-(4-fluoro-phenyl)-6-mercapto-nicotinamide

: 1240494-14-7
6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: potassium hydrogen difluoride / water; methanol / 1 h

With potassium hydrogen difluoride; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide;