6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Base Information

Chemical Name:6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide
CAS No.:1240494-30-7
Molecular Formula:C₂₆H₂₅BF₄N₂O₄S
Molecular Weight:548.366
Hs Code.:

Synonyms:6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

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Chemical Property of 6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Chemical Property:

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Technology Process of 6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

There total 3 articles about 6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957066-13-6
2-bromomethyl-4-trifluoromethoxy-phenylboronic acid pinacol ester

: N-(4-fluoro-phenyl)-6-mercapto-nicotinamide

: 1240494-30-7
6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

: 17624-07-6,92823-43-3
6-Mercapto-nicotinic acid

: 1240494-30-7
6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 12 h

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1240494-30-7
6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 12 h

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;