Technology Process of 3-[4-(2-methyl-2,3-dihydroindol-1-ylmethyl)phenyl]isoxazole-5-carboxylic acid amide
There total 8 articles about 3-[4-(2-methyl-2,3-dihydroindol-1-ylmethyl)phenyl]isoxazole-5-carboxylic acid amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methyl indoline;
With
sodium (triacetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
3-(4-formylphenyl)isoxazole-5-carboxylic acid amide;
With
acetic acid;
In
1,2-dichloro-ethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 14 h
2.1: diisobutylaluminium hydride / toluene / 2 h / 0 - 20 °C / Inert atmosphere
3.1: pyridine; hydroxylamine hydrochloride / ethanol
4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 0 °C
5.1: sodium L-ascorbate; copper(II) sulfate; potassium hydrogencarbonate / water; tert-butyl alcohol / 2.5 h / 20 °C
6.1: pyridine hydrogenfluoride / tetrahydrofuran / 5.5 h / 20 °C
7.1: Dess-Martin periodane / dimethyl sulfoxide / 2.5 h / 20 °C
8.1: sodium (triacetoxy)borohydride / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere
8.2: 20 °C
With
pyridine; 1H-imidazole; N-chloro-succinimide; sodium (triacetoxy)borohydride; hydroxylamine hydrochloride; diisobutylaluminium hydride; potassium hydrogencarbonate; Dess-Martin periodane; pyridine hydrogenfluoride; copper(II) sulfate; sodium L-ascorbate;
In
tetrahydrofuran; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine; hydroxylamine hydrochloride / ethanol
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 0 °C
3.1: sodium L-ascorbate; copper(II) sulfate; potassium hydrogencarbonate / water; tert-butyl alcohol / 2.5 h / 20 °C
4.1: pyridine hydrogenfluoride / tetrahydrofuran / 5.5 h / 20 °C
5.1: Dess-Martin periodane / dimethyl sulfoxide / 2.5 h / 20 °C
6.1: sodium (triacetoxy)borohydride / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere
6.2: 20 °C
With
pyridine; N-chloro-succinimide; sodium (triacetoxy)borohydride; hydroxylamine hydrochloride; potassium hydrogencarbonate; Dess-Martin periodane; pyridine hydrogenfluoride; copper(II) sulfate; sodium L-ascorbate;
In
tetrahydrofuran; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;
