4-(((Tert-butyldimethylsilyl)oxy)methyl)benzaldehyde

Base Information

• Chemical Name: 4-(((Tert-butyldimethylsilyl)oxy)methyl)benzaldehyde
• CAS No.: 160744-60-5
• Molecular Formula: C14H22 O2 Si
• Molecular Weight: 250.413
• DSSTox Substance ID: DTXSID80446523
• Nikkaji Number: J1.359.939D
• Mol file: 160744-60-5.mol

Synonyms:160744-60-5;4-(tert-butyl-dimethyl-silanyloxymethyl)-benzaldehyde;4-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde;4-(tert-Butyldimethylsiloxymethyl)benzaldehyde;4-[[tert-butyl(dimethyl)silyl]oxymethyl]benzaldehyde;4-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL)BENZALDEHYDE;SCHEMBL979052;DTXSID80446523;KUTMKNOUAVFJEA-UHFFFAOYSA-N;4-(t-Butyldimethylsilyloxymethyl)benzaldehyde;FT-0733990;4-(tert-Butyldimethylsilyloxymethyl)benzaldehyde;4-(tert-Butyldimethylsilanyloxymethyl)benzaldehyde;4-(tert-Butyldimethyl-silanyloxymethyl)-benzaldehyde;A1-15158;4-({[tert-butyl(dimethyl)silyl]oxy}methyl)benzaldehyde

Chemical Property of 4-(((Tert-butyldimethylsilyl)oxy)methyl)benzaldehyde

Chemical Property:

• Boiling Point: 313.2±17.0 °C(Predicted)
• PSA: 26.30000
• Density: 0.968±0.06 g/cm3(Predicted)
• LogP: 4.02090
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 250.138906475
• Heavy Atom Count: 17
• Complexity: 247

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OCC1=CC=C(C=C1)C=O

Technology Process of 4-(((Tert-butyldimethylsilyl)oxy)methyl)benzaldehyde

There total 20 articles about 4-(((Tert-butyldimethylsilyl)oxy)methyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl-(4-diethoxymethyl-benzyloxy)-dimethyl-silane → 4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde (160744-60-5)

Guidance literature:

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In water; at 30 ℃; for 0.0833333h;

DOI:10.1055/s-2007-968009

Reference yield: 99.0%

[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol (118992-89-5) → 4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde (160744-60-5)

Guidance literature:

With oxygen; caesium carbonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In toluene; at 100 ℃; for 1h;

DOI:10.1016/S0040-4039(00)01284-3

Reference yield: 99.0%

terephthalaldehyde, (623-27-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde (160744-60-5)

Guidance literature:

terephthalaldehyde,; With 1H-imidazole; In dichloromethane; at 20 ℃; for 0.5h;

tert-butyldimethylsilyl chloride; at 20 ℃; for 6h;

DOI:10.1039/c9ob01076a

upstream raw materials:

tert-butyldimethylsilyl chloride

4-(hydroxylmethyl)benzaldehyde

[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol

4-(tert-butyldimethylsiloxymethyl)bromobenzene

Downstream raw materials:

4-(tert-butyldimethylsilyloxymethyl)-N-(trimethylsilyl)benzaldimine

[4-[(tert-Butyldimethylsiloxy)methyl]phenyl]-(pyridin-3-yl)carbinol

2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid diethyl ester

C₃₁H₅₀N₂O₅Si