para-Methoxyamphetamine Hydrochloride

Base Information

• Chemical Name: para-Methoxyamphetamine Hydrochloride
• CAS No.: 50505-80-1
• Molecular Formula: C10H15 N O . Cl H
• Molecular Weight: 201.696
• Hs Code.: 2922299090
• UNII: Q8VR834JGY
• Mol file: 50505-80-1.mol

Synonyms:50505-80-1;para-Methoxyamphetamine Hydrochloride;Pma hydrochloride, (R)-;Q8VR834JGY;4-Ma hydrochloride, (R)-;SCHEMBL10975159;Pma (psychedelic) hydrochloride, (R)-;4-Methoxyamphetamine hydrochloride, (R)-;Para-methoxyamphetamine hydrochloride, (R)-;(R)-1-(4-Methoxyphenyl)propan-2-amine HCl;Benzeneethanamine, 4-methoxy-alpha-methyl-, hydrochloride, (R)-;Benzeneethanamine, 4-methoxy-alpha-methyl-, hydrochloride (1:1), (alphaR)-;Benzeneethanamine, 4-methoxy-alpha-methyl-, hydrochloride, (alphaR)-

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Chemical Property of para-Methoxyamphetamine Hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 3.08720
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 119

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)OC)N.Cl
• Isomeric SMILES: C[C@H](CC1=CC=C(C=C1)OC)N.Cl
• Uses: Amphetamine (A634240) analogue, a known hallucinogen,

Technology Process of para-Methoxyamphetamine Hydrochloride

There total 12 articles about para-Methoxyamphetamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C15H21NO6S → l-para-Methoxyamphetamine hydrochloride (50505-80-1,50505-81-2,52740-56-4)

Guidance literature:

C₁₅H₂₁NO₆S; With sodium tetrahydroborate; lithium chloride; In diethylene glycol dimethyl ether; at 80 ℃; for 24h;

With hydrogenchloride; In ethyl acetate; at 30 ℃; for 12h;

Reference yield: 86.0%

N-Cbz-2-(4-methoxyphenyl)-1-methylethylamine (115424-09-4) → l-para-Methoxyamphetamine hydrochloride (50505-80-1,50505-81-2,52740-56-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1080/00397919808007167

Reference yield:

(+)-(R)-N-(1-phenylethyl)-N-[1-(p-methoxyphenyl)-2-propyl]amine hydrochloride (50505-66-3) → l-para-Methoxyamphetamine hydrochloride (50505-80-1,50505-81-2,52740-56-4)

Guidance literature:

(+)-(R)-N-(1-phenylethyl)-N-[1-(p-methoxyphenyl)-2-propyl]amine hydrochloride; With hydrogen; palladium 10% on activated carbon; In methanol; at 50 ℃; for 8 - 10h;

With hydrogenchloride; In methanol; isopropyl alcohol; pH=1 - 2;

upstream raw materials:

N-Cbz-2-(4-methoxyphenyl)-1-methylethylamine

L-tyrosine ethyl ester

N-[(phenylmethoxy)carbonyl]-L-tyrosine

L-tyrosine

Downstream raw materials:

(R)-N-trimethylsilyl-[2-(p-methoxyphenyl)-1-methylethyl]amine

8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)amino]ethyl}carbostyril

(R)-(-)-p-methoxyamphetamine

8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((lR)-2-(p-methoxy phenyl)-1-methylethyl) amino] ethyl} carbostyril hydrochloride